Promethazine HCl and Codeine Phosphate Oral Answer need to be utilised with caution in clients with impairment of hepatic purpose, and patients really should be monitored closely for respiratory despair, sedation, and hypotension.

Get medical aid right away in case you see any of the subsequent: slow/shallow breathing, critical drowsiness/problems waking up, confusion.

Limited information suggest that use of promethazine hydrochloride through labor and shipping and delivery doesn't have an appreciable effect on the length of labor or shipping and delivery and won't enhance the possibility of have to have for intervention in the new child.

Promethazine and codeine mixture is utilized to relieve cough, runny or stuffy nose, sneezing, or other signs and symptoms caused by allergic reactions or maybe the frequent chilly.

Promethazine must be utilised with caution in individuals with bone marrow melancholy. Leukopenia and agranulocytosis have already been noted, usually when promethazine HCl continues to be Utilized in Affiliation with other identified marrow-poisonous agents.

Clinical research of promethazine hydrochloride and codeine phosphate syrup didn't involve ample figures of subjects aged 65 and in excess of to ascertain whether or not they respond in different ways from youthful subjects. Other described clinical expertise has not discovered variances in responses amongst the elderly and young people.

Keep away from the usage of Promethazine HCl and Codeine Phosphate Oral Remedy in adolescents 12 to eighteen several years of age who have other danger variables that could maximize their sensitivity to your respiratory depressant results of codeine. Hazard factors contain disorders affiliated with hypoventilation, for example postoperative status, obstructive slumber apnea, weight problems, significant pulmonary sickness, neuromuscular disease, and concomitant use of other medicines that bring about respiratory depression.

Advise sufferers to normally use an precise milliliter measuring unit when measuring and administering Promethazine HCl and Codeine Phosphate Oral Resolution. Advise individuals that a residence teaspoon is just not an exact measuring device and these types of use may lead to overdosage and major adverse reactions [see Overdosage (ten)].

Overdose of codeine in Grownups has been connected to fatal respiratory despair, and the use of codeine in small children youthful than 12 years of age has actually been affiliated with lethal respiratory depression when made use of as advisable [see Warnings and Safety measures (5.

Outcomes over the Gastrointestinal Tract as well as other Clean Muscle mass Codeine leads to a reduction in motility connected to a rise in smooth muscle mass tone during the antrum from the abdomen and duodenum. Digestion of food stuff within the little intestine is delayed and propulsive contractions are diminished.

If you're extremely sleepy or have issues waking up just after applying this medication, stop getting this medication and speak to your medical professional or pharmacist straight away. Your dosage may well need to be reduce.

Codeine Promethazine codeine syrup is described to show no evidence of carcinogenicity or mutagenicity in a number of examination techniques, including the micronucleus and sperm abnormality assays along with the Salmonella assay. Promethazine was nonmutagenic from the Salmonella examination procedure of Ames.

Consider this medication by mouth which has a glass of drinking water. Should the medication upsets your belly, choose it with foods or milk. Stick to the Instructions to the prescription label. Do not get greater than you will be explained to to consider.

The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals below six years of age, for the reason that the combination may possibly cause fatal respiratory depression In this particular age inhabitants. It is crucial that promethazine with codeine syrup is calculated by having an correct measuring unit (see Safety measures-Information and facts For Individuals).